Solitary bone plasmocytoma of the spine in an adolescent
Identifieur interne : 000C23 ( France/Analysis ); précédent : 000C22; suivant : 000C24Solitary bone plasmocytoma of the spine in an adolescent
Auteurs : C. Dumesnil [France] ; P. Schneider [France] ; I. Dolgopolov [Russie] ; S. Radi [France] ; B. Leluyer [France] ; J. P. Vannier [France]Source :
- Pediatric Blood & Cancer [ 1545-5009 ] ; 2006-09.
English descriptors
- KwdEn :
Abstract
Solitary plasmocytoma (SP) represent only about 5% of plasma cell neoplasia. Most patients have generalized disease, that is, multiple myeloma (MM). Solitary bone plasmocytoma (SBP) is a localized plasma cell tumor and is a very rare disease in young patients. We reported here, a case of SPB in a 14‐year‐old girl with a 10‐year disease‐free survival after an aggressive treatment. The relationship of SBP to MM continues to be controversial. Recommendations on the diagnosis and management of SBP in adults, based on a literature search and consensus of expert opinion, were recently published on behalf of the Guidelines Working Group of the United Kingdom Myeloma Forum 1. MRI of the spine is necessary to assess local disease. Radiotherapy with doses of 45–50 Gy is the recommended treatment and gives a high rate of local control (83–96%). Chemotherapy remains controversial in contrast to MM, in which intensive chemotherapy with autologous bone marrow transplantation (ABMT) is widely accepted. At the present time, considering the good prognosis of patients with a normal MRI at diagnosis and a complete disappearance of the M protein after radiotherapy, we believe that ABMT should be reserved for relapse or primary therapeutic failure. Pediatr Blood Cancer 2006;47:335–338. © 2005 Wiley‐Liss, Inc.
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DOI: 10.1002/pbc.20493
Affiliations:
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ISTEX:A91B08C3DDE945F41889C364E52C0D3860417ABDLe document en format XML
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Blood Cancer</title><idno type="ISSN">1545-5009</idno><idno type="eISSN">1545-5017</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-09">2006-09</date><biblScope unit="volume">47</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="335">335</biblScope><biblScope unit="page" to="338">338</biblScope></imprint><idno type="ISSN">1545-5009</idno></series><idno type="istex">A91B08C3DDE945F41889C364E52C0D3860417ABD</idno><idno type="DOI">10.1002/pbc.20493</idno><idno type="ArticleID">PBC20493</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1545-5009</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>autologous stem cell transplantation</term><term>children</term><term>high dose chemotherapy</term><term>solitary bone plasmocytoma</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Solitary plasmocytoma (SP) represent only about 5% of plasma cell neoplasia. Most patients have generalized disease, that is, multiple myeloma (MM). Solitary bone plasmocytoma (SBP) is a localized plasma cell tumor and is a very rare disease in young patients. We reported here, a case of SPB in a 14‐year‐old girl with a 10‐year disease‐free survival after an aggressive treatment. The relationship of SBP to MM continues to be controversial. Recommendations on the diagnosis and management of SBP in adults, based on a literature search and consensus of expert opinion, were recently published on behalf of the Guidelines Working Group of the United Kingdom Myeloma Forum 1. MRI of the spine is necessary to assess local disease. Radiotherapy with doses of 45–50 Gy is the recommended treatment and gives a high rate of local control (83–96%). Chemotherapy remains controversial in contrast to MM, in which intensive chemotherapy with autologous bone marrow transplantation (ABMT) is widely accepted. At the present time, considering the good prognosis of patients with a normal MRI at diagnosis and a complete disappearance of the M protein after radiotherapy, we believe that ABMT should be reserved for relapse or primary therapeutic failure. Pediatr Blood Cancer 2006;47:335–338. © 2005 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>France</li><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Le Havre</li><li>Moscou</li><li>Rouen</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Dumesnil, C" sort="Dumesnil, C" uniqKey="Dumesnil C" first="C." last="Dumesnil">C. Dumesnil</name></noRegion><name sortKey="Leluyer, B" sort="Leluyer, B" uniqKey="Leluyer B" first="B." last="Leluyer">B. Leluyer</name><name sortKey="Radi, S" sort="Radi, S" uniqKey="Radi S" first="S." last="Radi">S. Radi</name><name sortKey="Schneider, P" sort="Schneider, P" uniqKey="Schneider P" first="P." last="Schneider">P. 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